SCRIPT-AML
Clinical study on conditioning regimens before paediatric transplantation in acute myeloid leukaemia
SCRIPT-AML is an international clinical study examining the chemotherapy used during the conditioning phase before stem cell transplantation in children, adolescents, and young adults with acute myeloid leukaemia (AML). The main objective of the study is to compare the tolerability and efficacy of two different conditioning regimens used to treat AML in children and adolescents. The study comprises several parts: an interventional part involving randomisation (random distribution of participants into different groups) and an observational part.
Is this study suitable for my child’s condition?
Leukaemia, lymphoma and bone marrow disease
- Acute lymphoblastic leukemia (ALL)
- Acute myeloid leukemia (AML)
- Chronic myeloid leukemia (CML)
- Myelodysplastic syndrome (MDS)
- Severe aplastic anemia (SAA)
- Non-Hodgkin lymphoma
- Hodgkin lymphoma
- Other leukaemia, lymphoma and bone marrow disease
Brain and spinal cord tumors
- Low-grade glioma
- High-grade glioma
- Diffuse-intrinsic pontine glioma (DIPG) / Diffuse midline glioma (DMG)
- Medulloblastoma
- Atypical teratoid rhabdoid tumours (ATRT)
- Ependymoma
- Germ cell tumours / germinoma / nongerminomatous germ cell tumours / teratoma (brain / spinal cord)
- Craniopharyngioma
- Other brain tumours or spinal cord tumours
Solid tumors
- Wilms tumours / nephroblastoma
- Neuroblastoma
- Rhabdomyosarcoma
- Ewing sarcoma
- Osteosarcoma
- Rhabdoid tumours (other than brain or spinal cord)
- Other sarcoma
- Germ cell tumours (other than brain or spinal cord)
- Retinoblastoma
- Hepatoblastoma
- Other solid tumours
Study Information
What age range of children can participate?
Up to 21 years
Official Study Information
Study at www.humanforschung-schweiz.ch
Study at www.clinicaltrials.gov
Questions? Please contact your medical team.
If you would like more information about a study, please speak to your child’s treating physician. They are your primary point of contact and can provide personalized advice and support. If no treatment team is currently in place, you can find general contact information for the study sites on the map below.
Treatment Centers with Open Study – Map & Overview
The map shows all treatment sites in Switzerland. Locations where the study is currently open are marked in blue. You can find contact details by clicking on the towns. The information on study sites is updated regularly. However, a study may occasionally open at a new site before this is reflected on the platform. If in doubt, please contact your treatment team or one of the listed clinics directly.
Basel
Universitäts-Kinderspital beider Basel UKBB
Spitalstrasse 33
4056 Basel
+41 61 704 12 12
www.ukbb.ch
Genève
HUG Hôpitaux Universitaires Genève
Département de la Femme, de l’Enfant et Adolescent (DFEA)
Service de Pédiatrie Générale
Hôpital des Enfants
Rue Willy-Donzé 6
1205 Genève
Téléphone: +41 22 372 40 00
https://enfants-ados.hug.ch/hopital-enfants
https://www.hug.ch/departement-femme-enfant-ado/services-medicaux
Unité d’Oncologie et Hématologie Pédiatrique (UOHP)
Téléphone: +41 22 372 47 31
https://enfants-ados.hug.ch/specialites-medicales-chirurgicales/oncologie-hematologie-pediatrique
Plateforme de recherche CANSEARCH en Oncologie et Hématologie pédiatrique,
Département de Pédiatrie, Gynécologie et Obstétrique
Université de Genève
Centre Médical
Téléphone: +41 79 553 61 00
Email : plateforme-cansearch@unige.ch
https://www.unige.ch/medecine/petri/groupes-de-recherche/907ansari
Zürich
Universitäts-Kinderspital Zürich –
Eleonorenstiftung
Lenggstrasse 30
8008 Zürich
https://www.kispi.uzh.ch
Sekretariat Onkologie
Telefon: +41 44 249 63 50
E-Mail: onkologie.sekretariat@kispi.uzh.ch